SphK1-IN-3 is an effectivesphingosine kinase-1 (SphK1)inhibitor. SphK1-IN-3 inhibitsSphK1kinase activity with anIC₅₀value of 2.48 μM. SphK1-IN-3 can be used for the research of many diseases such ascancer, rheumatoid arthritis, diabetes, asthma, and pulmonary fibrosis^[1].

SphK1-IN-3 (Compound 47) efficiently inhibits SphK1 kinase activity with an IC₅₀value of 2.48 μM^[1].
SphK1-IN-3 (0-31.1 μM) exhibits significant decrease in the fluorescence intensity of SphK1 as well as formed stable protein-ligand complexes^[1].
SphK1-IN-3 shows effective inhibitory potential toward SphK1 in enzyme inhibition assay^[1].
SphK1-IN-3 (10 μM) demonstrates effective antitumor activity and growth inhibitory potential toward cancer cell lines^[1].
SphK1-IN-3 fits well into the ATP-binding site of SphK1 and form significant hydrogen-bonding interactions with catalytically relevant residues as predicted by molecular docking^[1].

404.42

C₂₁H₂₀N₆O₃

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