CAY10614 是一种有效的 TLR4 拮抗剂。
| Cas No. | 1202208-36-3 |
| 化学名 | N-cyclopentyl-N,N-dimethyl-3,4-bis(tetradecyloxy)-benzenemethanaminium, iodide |
| Canonical SMILES | CCCCCCCCCCCCCCOC1=CC=C(C[N+](C)(C)C2CCCC2)C=C1OCCCCCCCCCCCCCC.[I-] |
| 分子式 | C42H78INO2 |
| 分子量 | 756 |
| 溶解度 | DMF: 0.15 mg/ml,DMSO: 0.14 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Lipid A is a lipid-rich component of endotoxin, also known as lipopolysaccharide (LPS), which in turn is part of the outer membrane of Gram-negative bacteria. Lipid A activates toll-like receptor 4 (TLR4), initiating an immune response. CAY10614 is an antagonist of lipid A activation of TLR4, exhibiting an IC50 value of 1.68 μM in a cell-based assay using modified human embryonic kidney (HEK) cells. It does not significantly affect HEK cell viability. In a model of sepsis, CAY10614 dramatically and significantly improves survival of mice given intraperitoneal LPS. |
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