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H-L-Phe(4-NH-Poc)-OH hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
H-L-Phe(4-NH-Poc)-OH hydrochloride图片
CAS NO:2737202-66-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
H-L-Phe(4-NH-Poc)-OH (hydrochloride) 是一种含有叠氮基团的点化学试剂。在蛋白质和多肽生物合成中用作修饰的苯丙氨酸或 Tyr 类似物。丙炔基氧羰基,通常缩写为 Poc 或 Pryoc,既可作为标准咔嗒共轭的炔元组分,也可与无铜 Diels-Alder 型咔嗒反应中的四氮连接剂结合使用。它还可作为胺类、羟基和酯类的特殊保护基团。所有 3 种都是稳定的整齐 TFA,但可以在环境温度下与 Co2(CO)8 的 TFA:DCM 裂解。与其他过渡金属如钯的去保护也有报道。
生物活性

H-L-Phe(4-NH-Poc)-OH (hydrochloride) is aclick chemistryreagent containing an azide group. Used as a modified Phe or Tyr analogue in protein and peptide biosynthesis. Propargyloxycarbonyl, commonly abbreviated as Poc or Pryoc, can either be used as alkyne component for standard Click conjugation or in combination with tetrazine linkers in copper-free Diels-Alder type Click reactions. It also has applications as unusual protecting group for amines, hydroxy functions and as esters. All 3 are stable to neat TFA, but can be cleaved at ambient temperature with Co2(CO)8 in TFA:DCM. Deprotection with other transition metals like palladium have also been reported[1][2].

分子量

298.72

Formula

C13H15ClN2O4

CAS 号

2737202-66-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.