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PXS-6302
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PXS-6302图片
CAS NO:2584947-54-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PXS-6302 是一种不可逆赖氨酸氧化酶 (LOX) 抑制剂,IC50分别为 3.7 μM (Bovine LOX),3.4 μM (rh LOXL1),0.4 μM (rh LOXL2),1.5 μM (rh LOXL3),0.3 μM (rh LOXL4)。PXS-6302 易穿透皮肤,能够减少胶原蛋白沉积,显著改善疤痕外观。
生物活性

PXS-6302 is an irreversiblelysyl oxidaseinhibitor withIC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance[1].

IC50& Target

3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4)[1]

体外研究
(In Vitro)

PXS-6302 demonstrates high permeability to across a monolayer of cells, such as Caco-2 or MDCKII cells[1].

体内研究
(In Vivo)

PXS-6302 inhibits LOX, reduces crosslinking and improves scar appearance in porcine models of excisional and burn injury[1].
PXS-6302 (1.5%, oil in water cream; 500 mg cream applied to 16 cm2; external application; once daily, for 28 days) reduces collagen deposition and cross-linkin in murine models of injury and fibrosis under topical application[1].
PXS-6302 (0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2; external application; once daily, for 12 weeks) also significantly improves scar appearance without reducing tissue strength in porcine injury models under topical application[1].

Animal Model:Porcine excision injury model (female Juvenile pigs, 18-20 kg)[1]
Dosage:0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2
Administration:External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.
分子量

265.25

Formula

C10H10F3NO2S

CAS 号

2584947-54-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.