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Gd-NMC-3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gd-NMC-3图片
CAS NO:2678579-76-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Gd-NMC-3 是一种近红外荧光/磁共振 (NIRF/MR) 双峰成像探针。Gd-NMC-3 在肿瘤成像中具有高分辨率和灵敏度,并且生物相容性好。
生物活性

Gd-NMC-3 is a near-infrared fluorescence/magnetic resonance (NIRF/MR) bimodal imaging probe. Gd-NMC-3 shows high resolution and sensitivity in tumor imaging with good biocompatibility, indicating huge application potential[1].

体外研究
(In Vitro)

Gd-NMC-3 shows the maximum excitation wavelength and emission wavelength are 755 and 792 nm, respectively. Both wavelengths are located in the near-infrared region[1].
Gd-NMC-3 acts as a bimodal imaging molecule, can be accumulated in tumor sites[1].
Gd-NMC-3 (50 μM; 24 h) can be internalized into cancer cells by OATPs and NTCP, indicating an excellent specificity to tumor tissues[1].
Gd-NMC-3 (6.25-800 μM, 24 h) exhibits significant fluorescence accumulation (with the optimal concentration of 100, 200 μM) and reasonable relaxation property (11.64 M/m/s) in tumors[1].
Gd-NMC-3 (6.25-100 μM, 48 h) displays low cytotoxicity and good biocompatibility[1].

Cell Cytotoxicity Assay[1]

Cell Line:HepG2 and LM3: human hepatocarcinoma cell line; L02: human hepatocyte cell line
Concentration:6.25-100 μM
Incubation Time:48 hours
Result:Resulted more than 90% cell viability maintained after 48 h.
体内研究
(In Vivo)

Gd-NMC-3 (20 mg/kg; i.v.) holds an excellent tumor targeting ability, shows high resolution and sensitivity and provides real-time visual navigation in LM3 orthotopic and subcutaneous tumor models to guide the resection of tumors[1].

Animal Model:HepG2 subcutaneous xenograft mice[1]
Dosage:20 mg/kg
Administration:Intravenous injection; 1.5 h later dissected tumors
Result:Accumulated in the tumor after injection and produced stronger fluorescence intensity in tumor tissues.
Remained fluorescence signal longer than 1.5 h, and provided high-resolution images of the tumor tissues with a SNR of 4.32.
Animal Model:LM3 orthotopic mice[1]
Dosage:20 mg/kg
Administration:Intravenous injection
Result:Decreased gradually the fluorescence intensity in LM3 orthotopic liver tumors after administration, whereas tumor-to-skin fluorescence ratios increased due to high accumulation and low clearance in tumor tissues.
分子量

1968.46

Formula

C77H116Gd2N14O22S2

CAS 号

2678579-76-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.