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Dasabuvir sodium
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dasabuvir sodium图片
CAS NO:1132940-11-4
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
ABT-333 sodium
产品介绍
Dasabuvir (ABT-333) sodium 是一种非核苷丙型肝炎病毒 (HCV) 聚合酶抑制剂。Dasabuvir sodium 可抑制 HCV NS5B 基因编码的 RNA 依赖性 RNA 聚合酶 (RNA polymerase)。Dasabuvir sodium 对基因型 1a (菌株 H77) 和 1b (菌株 Con1) 复制子的有抑制作用,EC50值分别为 7.7 和 1.8 nM。
生物活性

Dasabuvir (ABT-333) sodium is a nonnucleosidehepatitis C virus (HCV) polymeraseinhibitor. Dasabuvir sodium inhibits RNA-dependentRNA polymeraseencoded by theHCVNS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, withEC50values of 7.7 and 1.8 nM, respectively[1].

IC50& Target

IC50: 2.2 ± 0.3 nM (HCV genotype 1b N), 2.8 ± 0.2 nM (HCV genotype 1a H77), 3.1 ± 0.21 nM (HCV genotype 1b BK), 0.7 ± 1.4 nM (HCV genotype 1b Con1)[1]

体外研究
(In Vitro)

Dasabuvir (ABT-333) sodium is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases[1].
Dasabuvir sodium inhibits the polymerase enzymatic activity of genotype 1 laboratory strain enzymes (H77, BK, N, and Con1 strains), as well as enzymes produced from polymerase genes from HCV genotype 1-infected subjects, with IC50s between 2.2 and 10.7 nM[1].
Dasabuvir sodium inhibits replication of HCV subgenomic replicons in cell culture assays, with EC50values of 7.7 and 1.8 nM against genotype 1a (H77) and 1b (Con1), respectively. In the presence of 40% human plasma, there is a 12- to 13-fold decrease in inhibitory potency, yielding EC50s of 99 and 21 nM for HCV genotype 1a (H77) and 1b (Con1) replicons, respectively[1].

Clinical Trial
分子量

516.56

Formula

C26H27N3NaO5S

CAS 号

1132940-11-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.