CAS NO: | 1132940-11-4 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Dasabuvir (ABT-333) sodium is a nonnucleosidehepatitis C virus (HCV) polymeraseinhibitor. Dasabuvir sodium inhibits RNA-dependentRNA polymeraseencoded by theHCVNS5B gene. Dasabuvir sodium inhibits genotype 1a (strain H77) and 1b (strain Con1) replicons, withEC50values of 7.7 and 1.8 nM, respectively[1]. |
IC50& Target | IC50: 2.2 ± 0.3 nM (HCV genotype 1b N), 2.8 ± 0.2 nM (HCV genotype 1a H77), 3.1 ± 0.21 nM (HCV genotype 1b BK), 0.7 ± 1.4 nM (HCV genotype 1b Con1)[1] |
体外研究 (In Vitro) | Dasabuvir (ABT-333) sodium is at least 7,000-fold selective for the inhibition of HCV genotype 1 polymerases over human/mammalian polymerases[1]. |
Clinical Trial | |
分子量 | 516.56 |
Formula | C26H27N3NaO5S |
CAS 号 | 1132940-11-4 |
运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |