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Helenalin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Helenalin图片
CAS NO:6754-13-8
包装与价格:
包装价格(元)
500 μg电议
1mg电议
5mg电议
10mg电议

产品介绍
Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子NF-κB。Helenalin 具有烷基化活性,以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点,从而抑制其 DNA 结合。
生物活性

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factorNF-κBby directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit ofNF-κB, thereby inhibits its DNA binding[1][2].

体外研究
(In Vitro)

Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes[1].
The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression[3].

Western Blot Analysis[1]

Cell Line:Jurkat T cells
Concentration:10 μM
Incubation Time:20-120 minutes
Result:Caused complete inhibition of NF-κB DNA binding after 80 minutes.
体内研究
(In Vivo)

Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels[2].

Animal Model:Immature male ICR mice[2]
Dosage:25 mg/kg
Administration:i.p.; 6 to 12 hours
Result:Caused a rapid decrease in hepatic glutathione levels.
分子量

262.30

性状

Solid

Formula

C15H18O4

CAS 号

6754-13-8

结构分类
  • Terpenoids
  • Sesquiterpenes
来源
  • Plants
  • other families
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month
溶解性数据
In Vitro: 

DMSO : 100 mg/mL(381.24 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.8124 mL19.0621 mL38.1243 mL
5 mM0.7625 mL3.8124 mL7.6249 mL
10 mM0.3812 mL1.9062 mL3.8124 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。