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CLEFMA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CLEFMA图片
CAS NO:1246964-32-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CLEFMA 是一种具有抗肿瘤活性的姜黄素。CLEFMA 抑制肿瘤生长与 NF-κB 调节的抗炎和抗转移作用有关。
生物活性

CLEFMA is a curcuminoid with antitumor activity. CLEFMA inhibits tumor growth is associated with NF-κB-regulated anti-inflammatory and anti-metastatic effects[1][2].

体外研究
(In Vitro)

CLEFMA (1-100 μM; 24-72 h) has anti-proliferative activity[1].
CLEFMA inhibits the viability of H441 and A549 cells, with IC50s of 6.4 and 8.9 μM, respectively[2].
CLEFMA (5-10 μM; 24 h) induces apoptosis in H441 and A549 cells[2].
CLEFMA (1 and 10 μM; 24 h) induces autophagic death in H441 cells[1].
CLEFMA (1-20 μM) reduces the DNA-binding activity of NF-κB in H441 cells in a dose-dependent manner[2].

Cell Proliferation Assay[1]

Cell Line:PANC-1, MiaPaCa-2, PC-3 and H441 cells
Concentration:1, 10, 25, 100 μM
Incubation Time:24, 48, 72 h
Result:Inhibits cells proliferation in a dose-dependent manner.
体内研究
(In Vivo)

CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) inhibits tumor growth and suppresses the uptake of FDG in tumor tissue in a xenograft mouse model[2].
CLEFMA (0.2-0.4 mg/kg; i.p. daily for 4 weeks) down-regulates the expression of anti-apoptotic markers cIAP1, Bcl-xL, Bcl-2 and survivin, and induces the cleavage of pro-apoptotic protein BID and the expression of pro-apoptotic BAX in tumor tissue[2].

Animal Model:Male athymic nu/nu mice (4 weeks old) are injected H441 cells[2]
Dosage:0.2, 0.4 mg/kg
Administration:I.p. daily for 4 weeks
Result:Inhibited tumor growth up to 96% tumor at dose of 0.4 mg/kg.
分子量

442.29

Formula

C23H17Cl2NO4

CAS 号

1246964-32-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.