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Neocryptotanshinone
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Neocryptotanshinone图片
CAS NO:109664-02-0
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
新隐丹参酮
产品介绍
Neocryptotanshinone 是从丹参 (Salvia Miltiorrhiza) 分离得到的一种丹参二萜,通过抑制NF-κBiNOS信号来抑制脂多糖 (LPS) 诱导的炎症。
生物活性

Neocryptotanshinone, a fattyditerpenoidsfromSalvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression ofNF-κBandiNOSsignaling pathways[1][2].

IC50& Target

Target: NF-κB, iNOS[1]

体外研究
(In Vitro)

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways[1].
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells[1].
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages[1].

Cell Viability Assay[1]

Cell Line:RAW264.7 cells
Concentration:5, 10 and 20 μM
Incubation Time:24 hours
Result:Inhibited LPS-induced cell viability in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line:RAW264.7 cells
Concentration:20 μM
Incubation Time:24 hours
Result:Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.
体内研究
(In Vivo)

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)[3].

Animal Model:MSU-induced pain model in male ICR mice (weighing 20-25 g)[2]
Dosage:10, 25, 50 or 100 mg/kg
Administration:Oral gavage; for 30, 60, 120 min
Result:Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.
分子量

314.38

性状

Solid

Formula

C19H22O4

CAS 号

109664-02-0

中文名称

新隐丹参酮

结构分类
  • Terpenoids
  • Diterpenoids
  • Quinones
  • Naphthalene Quinones
来源
  • Plants
  • Compositae
  • Hemistepta lyrata
  • Plants
  • Labiatae
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(318.09 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.1809 mL15.9043 mL31.8086 mL
5 mM0.6362 mL3.1809 mL6.3617 mL
10 mM0.3181 mL1.5904 mL3.1809 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。