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Aeruginosin 865
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Aeruginosin 865图片
CAS NO:1611990-01-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Aeruginosin 865 是从地面蓝藻Nostoc sp. Lukesová 30/93 分离出来的,是首个同时含有脂肪酸和碳水化合物的铜绿素蛋白型肽。Aeruginosin 865 抑制NF-kB向核的转运。Aeruginosin 865 具有抗炎作用。
生物活性

Aeruginosin 865, isolated from terrestrial cyanobacteriumNostoc sp. Lukesová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation ofNF-kBto the nucleus. Aeruginosin 865 has anti-inflammatory effect[1]

体外研究
(In Vitro)

Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC50=3.5 μg/mL) and ICAM-1 (EC50=50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells[1].
Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells[2].
.

分子量

864.98

Formula

C41H64N6O14

CAS 号

1611990-01-2

结构分类
  • Phenols
  • Monophenols
  • Others
来源

Terrestrial cyanobacterium Nostoc sp

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.