Aeruginosin 865, isolated from terrestrial cyanobacteriumNostoc sp. Lukesová 30/93, is the first aeruginosin-type peptide containing both a fatty acid and a carbohydrate moiety. Aeruginosin 865 inhibits translocation ofNF-kBto the nucleus. Aeruginosin 865 has anti-inflammatory effect^[1]

Aeruginosin 865 (pretreatment with 0.1-100 μg/mL) shows significant inhibition of IL-8 (EC₅₀=3.5 μg/mL) and ICAM-1 (EC₅₀=50.0 μg/mL) in hTNF-α-stimulated HLMVECs in a concentration-dependent manner. Aeruginosin 865 does not affect cell viability, even at much higher concentration in HeLa, HepG2 cells^[1].
Aeruginosin 865 (100-200 μM) shows high-dose cytotoxicity in Mouse fibrosarcoma cells and with no cytotoxic effect in NIH/3T3 cells^[2].
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864.98

C₄₁H₆₄N₆O₁₄

1611990-01-2

• Phenols
• Monophenols

• Others

Terrestrial cyanobacterium Nostoc sp

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