您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Laurotetanine
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Laurotetanine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Laurotetanine图片
CAS NO:128-76-7
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
(+)-Laurotetanine
产品介绍
Laurotetanine ((+)-Laurotetanine) 是一种口服有效的异喹啉类生物碱,可从Litsea cubeba (Lour.) Pers的根中提取。Laurotetanine 通过下调MUC5ACNF-κB信号通路抑制 IgE、组胺和炎症反应发挥抗哮喘作用。
生物活性

Laurotetanine ((+)-Laurotetanine) is an potent and orally active isoquinoline alkaloid and could be extracted from the roots ofLitsea cubeba (Lour.) Pers. Laurotetanine exerts an anti-asthmatic effect by inhibition ofIgE, histamine, and inflammatory reactions via down-regulatingMUC5ACandNF-κBsignaling pathways[1].

体内研究
(In Vivo)

Laurotetanine ((+)-Laurotetanine; 20-60 mg/kg; p.o.; 每天,持续 21 天; SD 大鼠) 通过下调 MUC5AC 和 NF-κB 信号通路发挥抗哮喘作用。

Animal Model:Sprague Dawley (SD) rats (180-220g)[1]
Dosage:20, 40, and 60 mg/kg
Administration:Oral administration; daily, for 21 days
Result:Reduced inflammatory cells, including eosinophils, neutrophils, lymphocytes, and macrophages.
Decreased inflammatory cytokines viz IL-4, IL-6, IL-13 and increased IFN-γ.
Reduced serum IgE and histamine.
Decreased MUC5AC expression and increased NF-κB and IκB expression in lung tissues.
分子量

327.37

Formula

C19H21NO4

CAS 号

128-76-7

结构分类
  • Alkaloids
  • Isoquinoline Alkaloids
来源
  • Plants
  • Lauraceae
  • Lindera aggregata(Sims) Kosterm.
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.