SN52

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SN52

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1071173-56-2

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

SN52 是一种有效的、竞争性的、细胞通透性的NF-κB2抑制剂。SN52 是 SN50 肽的变体，抑制 p52-RelB 异二聚体的核易位。SN52 对前列腺癌细胞有很强的放射增敏作用。SN52 可以用于癌症研究。

生物活性

SN52 is a potent, competitive, and cell-permeable inhibitor ofNF-κB2. SN52 is a variant of the SN50 peptide and inhibits the nuclear translocation ofp52-RelBheterodimers. SN52 has a strong radiosensitization effect on prostatecancercells. SN52 can be used forcancerresearch^[1].

IC₅₀& Target

IC50: NF-κB2^[1]

体外研究
(In Vitro)

SN52 (40 μg/ml; 30 mins before DMXAA) inhibits DMXAA-induced nuclear translocation of RelB in BMDCs^[1].
SN52 does not change the activation of canonical NF-κB signaling. The nuclear translocation of RelB is increased in DCs isolated from irradiated tumors, and SN52 abolishes this activation in activated DC cells^[1].
SN52 (40 μg/mL; 30 mins before co-cultured with irradiated or non-irradiated MC38 cells) inhibits the non-canonical NF-κB and increases Ifn-b expression in BMDCs stimulated with irradiated tumor cells^[1].

体内研究
(In Vivo)

SN52 (intrathecal injection; 40 μg/ml; day-1, day 1 and day 3 of 20Gy radiation of radiation) combines with IR enhances anti-tumor immune functions of both DCs and CD8⁺ T cells and subsequently reduced tumor burden more effectively compared with IR alone^[1].

Animal Model:	Tumor mice model^[1]
Dosage:	40 μg
Administration:	Intrathecal injection; 40 μg; day-1, day 1 and day 3 of 20Gy radiation of radiation
Result:	Reduced tumor burden than IR group alone. Induced non-canonical NF-κB inhibition and potentiates the anti-tumor effect of IR.

分子量

2749.43

性状

Solid

Formula

C₁₂₈H₂₃₀N₃₈O₂₈

CAS 号

1071173-56-2

Sequence Shortening

AAVALLPAVLLALLAPVQRKRRKALP

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据

In Vitro:

H₂O : 25 mg/mL(9.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	0.3637 mL	1.8186 mL	3.6371 mL
5 mM	0.0727 mL	0.3637 mL	0.7274 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture and light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.
请依序添加每种溶剂： PBS
Solubility: 50 mg/mL (18.19 mM); Clear solution; Need ultrasonic

*以上所有助溶剂都可在本网站选购。