Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of bothCOX-1andCOX-2with IC50s of 2.2 μM and 36 μM for human plateletCOX-1and IL-1-stimulated human synovial cellCOX-2, respectively. Oxaprozin also inhibits the activation ofNF-κB.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

298.35

C₁₈H₁₀D₅NO₃

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.