12-HETE-d8 is the deuterium labeled 12-HETE. 12-HETE, a major metabolic product of arachidonic acid using12-LOXcatalysis, inhibits cellapoptosisin a dose-dependent manner. 12-HETE promotes the activation and nuclear translocation ofNF-κBthrough the integrin-linked kinase (ILK) pathway^[1].12-HETE has both anti-thrombotic and pro-thrombotic effects^[2]. 12-HETE is a neuromodulator^[3].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

328.52

C₂₀H₂₄D₈O₃

2525175-25-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.