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Lipoxin A4-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lipoxin A4-d5图片
CAS NO:1622429-53-1
包装:10 μg

产品名称
LXA4-d5
产品介绍
Lipoxin A4-d5 (LXA4-d5) 是 Lipoxin A4 的氘代物。Lipoxin A4 (LXA4) 是一种内源性脂氧合酶衍生的类二十烷酸调节剂,具有强大的抗炎和促消炎双重特性。Lipoxin A4 抑制与 ERK1/2 和 NF-kB 通路相关的人表皮角质形成细胞 (NHEK) 的增殖以及炎性细胞因子/趋化因子(如IL-6IL-8等)的产生。Lipoxin A4 抑制血清淀粉样蛋白 A (SAA) 介导的IL-8释放,IC50值为 25.74 nM。
生物活性

Lipoxin A4-d5 (LXA4-d5) is the deuterium labeled Lipoxin A4. Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving andanti-inflammatoryproperties[1]. Lipoxin A4 inhibits proliferation and inflammatory cytokine/chemokine production of human epidermal keratinocytes (NHEKs) associated with the ERK1/2 and NF-kB pathways[2]. Lipoxin A4 inhibits serum amyloid A (SAA)-mediatedIL-8release with an IC50value of 25.74 nM[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

357.50

Formula

C20H27D5O5

CAS 号

1622429-53-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.