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Carboxy-PTIO
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carboxy-PTIO图片
CAS NO:145757-47-7
包装:5mg

产品介绍
Carboxy-PTIO 是一种有效的一氧化氮 (NO) 清除剂,能与 NO 快速反应产生 NO2。Carboxy-PTIO 通过对脂多糖诱导大鼠模型中 NO 的直接清除作用,可预防低血压和内毒素休克。
生物活性

Carboxy-PTIO is a potentnitric oxide (NO)scavenger that can make a quick reaction with NO to produce NO2. Carboxy-PTIO can prevent hypotension and endotoxic shock through the direct scavenging action against NO in lipopolysaccharide-stimulated rat model[1][2][3].

体外研究
(In Vitro)

Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) significantly suppresses the stimulation of NO expression induced by physalin A treatment, but no change is observed in Carboxy-PTIO treatment alone[1].
Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) reduces physalin A-induced cleavage of procaspase-3 and PARP, down-regulated ICAD expression,diminishing DNA fragmentation in nuclei[1].
Carboxy-PTIO (200 μM; 1 h prior to physalin A; 24 hours) shows no effect on iNOS expression. However, decreased-mTOR and p-mTOR levels induced by physalin A is reversed by Carboxy-PTIO with concomitant suppression of LC3 I to LC3 II conversions in A375-S2 cells[1].

Cell Viability Assay[1]

Cell Line:A375-S2 cells
Concentration:200 μM
Incubation Time:1 h prior to physalin A; 24 hours
Result:Diminished physalin A-induced procaspase-3 and PARP cleavage.
体内研究
(In Vivo)

Carboxy-PTIO (intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min) treatment improves the hypotension, renal dysfunction and survival rate in Lps-treated rats. But it does not affect each parameter in naomal rats[3].

Animal Model:SD rats[3]
Dosage:0.056-1.70 mg/kg/min
Administration:Intravenous injection; 0.056-1.70 mg/kg/min; infused for 1 hr beginning 90 min after the LPS injection 90 min
Result:Exhibited a potent therapeutic value in endotoxin shock through the direct scavenging action against NO.
分子量

277.30

Formula

C14H17N2O4

CAS 号

145757-47-7

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.