CAS NO: | 116339-68-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | SKF-86002 dihydrochloride is an orally activep38 MAPKinhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyteIL-1and TNF-α production (IC50= 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid[1][2][3]. | ||||||||
体外研究 (In Vitro) | SKF-86002 dihydrochloride (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV)[1]. Western Blot Analysis[4]
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体内研究 (In Vivo) | SKF-86002 dihydrochloride (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity[5].
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分子量 | 370.27 | ||||||||
Formula | C16H14Cl2FN3S | ||||||||
CAS 号 | 116339-68-5 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |