您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > SKF-86002 dihydrochloride
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
SKF-86002 dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SKF-86002 dihydrochloride图片
CAS NO:116339-68-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
SKF-86002 dihydrochloride 是一种具有口服活性的p38 MAPK抑制剂,具有抗炎、抗关节炎活性,可用于缓解疼痛的研究。SKF-86002 dihydrochloride 抑制脂多糖 (LPS) 刺激人单核细胞产生 IL-1 和 TNF-α。SKF-86002 dihydrochloride 能抑制脂氧合酶和环氧合酶介导的花生四烯酸代谢。
生物活性

SKF-86002 dihydrochloride is an orally activep38 MAPKinhibitor, with anti-inflammatory, anti-arthritic and analgesic activities. SKF-86002 dihydrochloride inhibits lipopolysaccharide (LPS)-stimulate human monocyteIL-1and TNF-α production (IC50= 1 μM). SKF-86002 dihydrochloride inhibits lipoxygenase- and cyclooxygenase-mediated metabolism of arachidonic acid[1][2][3].

体外研究
(In Vitro)

SKF-86002 dihydrochloride (10 μM; 1 hour) inhibits apoptosis induced by stress stimulation with UV irradiation (UV)[1].
SKF-86002 dihydrochloride does not inhibit UV-induced apoptosis in undifferentiated HL-60 cells[1].
SKF-86002 dihydrochloride (10 μM; 72 hours) prevent IL-4-induced monocyte or U937 cell CD23 surface expression and protein formation with no effect on CD23 mRNA levels[4].

Western Blot Analysis[4]

Cell Line:U937 cells
Concentration:10 μM
Incubation Time:72 hours
Result:Reduced CD23 levels on IL-4-treated U937 cells.
体内研究
(In Vivo)

SKF-86002 dihydrochloride (10-90 mg/kg; p.o.; daily; for 22 days) has antiarthritic activity[5].

Animal Model:Lewis rats, with adjuvant-induced arthritis (AA)[5]
Dosage:10 mg/kg, 30 mg/kg, 90 mg/kg
Administration:Oral administration, daily, for 22 days
Result:Significantly decreased hindleg volumes after injection of adjuvant.
分子量

370.27

Formula

C16H14Cl2FN3S

CAS 号

116339-68-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.