PDE1-IN-4 (compound 2g) is a potent and selectivePDE1(phosphodiesterase-1) inhibitor, withIC₅₀values of 10, 145, and 354 nM forPDE1C,PDE1A, andPDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced byTGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research^[1].

PDE1-IN-4 (compound 2g) shows weak inhibition against the hERG channel with an IC₅₀above 40 μM, indicating that it will not cause cardiotoxicity^[1].

535.63

C₃₃H₃₃N₃O₄

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