CAS NO: | 2244517-61-9 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | PDE5-IN-2 is a potent, highly selective, and orally activePDE5inhibitor, with anIC50of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, withIC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1]. | |||||
IC50& Target[1] |
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体外研究 (In Vitro) | PDE5-IN-2 (Compound 3) has at least 1000-fold selectivity over PDE1B, PDE3A, PDE7A1, PDE8A1, and PDE9A2 (IC50s, >32 000 nM)[1]. | |||||
体内研究 (In Vivo) | PDE5-IN-2 (1.25 mg/kg, p.o.) shows anti-pulmonary arterial hypertension activity, decreases mean pulmonary artery pressure in rats[1]. | |||||
分子量 | 491.52 | |||||
Formula | C25H21N3O6S | |||||
CAS 号 | 2244517-61-9 | |||||
运输条件 | Room temperature in continental US; may vary elsewhere. | |||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |