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PDE5-IN-2
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PDE5-IN-2图片
CAS NO:2244517-61-9
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PDE5-IN-2 是一种有效、高度选择性、可口服的PDE5抑制剂,IC50值为 0.31 nM,对 PDE2A,PDE10A,PDE4D2 和 PDE6C 的选择性相对较弱,IC50值分别为 106,46,43,1.2 nM。抗肺动脉高压作用。
生物活性

PDE5-IN-2 is a potent, highly selective, and orally activePDE5inhibitor, with anIC50of 0.31 nM, less potently inhibits PDE2A, PDE10A, PDE4D2, and PDE6C, withIC50s of 106, 46, 43, 1.2 nM, respectively. Anti-pulmonary arterial hypertension activity[1].

IC50& Target[1]

PDE5A1

0.31 nM (IC50)

PDE6C

1.2 nM (IC50)

PDE4D2

43 nM (IC50)

PDE10A

46 nM (IC50)

PDE2A

106 nM (IC50)

体外研究
(In Vitro)

PDE5-IN-2 (Compound 3) has at least 1000-fold selectivity over PDE1B, PDE3A, PDE7A1, PDE8A1, and PDE9A2 (IC50s, >32 000 nM)[1].

体内研究
(In Vivo)

PDE5-IN-2 (1.25 mg/kg, p.o.) shows anti-pulmonary arterial hypertension activity, decreases mean pulmonary artery pressure in rats[1].

分子量

491.52

Formula

C25H21N3O6S

CAS 号

2244517-61-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.