BAY 2666605

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BAY 2666605

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2275774-60-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品介绍

BAY 2666605 是一种具有口服活性的PDE3A和PDE3B抑制剂，IC₅₀分别为 87 nM 和 50 nM。BAY 2666605 是一种PDE3A-SLFN12复合诱导剂 (WO2019025562A1; example 135)。

生物活性

BAY 2666605 is an orally activePDE3AandPDE3Binhibitor withIC₅₀s of 87 nM and 50 nM, respectively. BAY 2666605 is aPDE3A-SLFN12complex inducer (WO2019025562A1; example 135)^[1].

IC₅₀& Target^[1]

PDE3A

87 nM (IC₅₀)

PDE3B

50 nM (IC₅₀)

体外研究
(In Vitro)

BAY 2666605 (example 135) has anticancer effects, potently inhibit brain cancer(especially glioma, more specifically glioblastoma, astrocytoma), breast cancer (especially ductal carcinoma and adenocarcinoma), cervical cancer, AML(especially erythroleucemia), lung cancer(especially NSCLC adenocarcinoma and SCLC), skin cancer(especially melanoma), oesophagus cancer (especially squamous cell carcinoma), ovarian cancer, (especially teratocarcinoma, adenocarcinoma), pancreas cancer and prostatic cancer^[1].

体内研究
(In Vivo)

BAY 2666605 (5 mg/kg; p.o; twice daily) teatment shows anti-tumor efficacy in murine xenotransplantation models of human cancer^[1].

Clinical Trial

分子量

352.28

性状

Solid

Formula

C₁₇H₁₂F₄N₂O₂

CAS 号

2275774-60-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 250 mg/mL(709.66 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.8387 mL	14.1933 mL	28.3865 mL
5 mM	0.5677 mL	2.8387 mL	5.6773 mL
10 mM	0.2839 mL	1.4193 mL	2.8387 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。