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PF-03049423
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-03049423图片
CAS NO:402955-58-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
PF-03049423 (Compound PF-5) 是一种有效的,高选择性的phosphodiesterase-5A抑制剂,对大鼠和人血小板酶的IC50约为 0.2 nM。PF-03049423 可用于急性缺血性中风的研究。
生物活性

PF-03049423 (Compound PF-5) is a potent and highly selectivephosphodiesterase-5Ainhibitor with anIC50of about 0.2 nM for rat and human platelet enzyme. PF-03049423 can be used for the research of acute ischaemic stroke[1].

IC50& Target[1]

PDE5A

 

rat and human platelet enzyme

~0.2 nM (IC50)

体内研究
(In Vivo)

PF-03049423 (Compound PF-5) (1-10 mg/kg; s.c.; b.i.d. for 7 days) promotes functional recovery in a rat model of severe stroke induced by permanent middle cerebral artery occlusion[1].
PF-03049423 (1.0 mg/kg b.i.d. or 0.6 mg/kg q.d. for 7 days) improves poststroke sensory–motor behavioral outcome even when the treatment is initiated 24-72 hours after occlusion[1].

Animal Model:Male Sprague-Dawley rats, middle cerebral artery occlusion (MCA-o) model[1]
Dosage:0.1, 1, or 10 mg/kg
Administration:Subcutaneous injection, b.i.d. for 7 days
Result:Improved functional recovery at 1 mg/kg and 10 mg/kg.
Clinical Trial
Formula

C24H32N6O4.xHCl

CAS 号

402955-58-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.