Sudubrilimab (HS636) 是一种针对PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1 受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1 通路和 TGF-β 生物活性。
| 生物活性 | Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody againstPDL1. Sudubrilimab is fused at the C terminus of the heavy chain to aTGF-β1receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester thePD-1/PD-L1pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment[1]. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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