PD173952

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PD173952

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

305820-75-1

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

PD173952 是一种酪氨酸激酶抑制剂，对Lyn、Abl和Csk的IC₅₀分别为 0.3、1.7 和 6.6 nM。PD173952 也是Myt1抑制剂，K_i为 8.1 nM。PD173952 诱导凋亡 (apoptosis)。

生物活性

PD173952 is atyrosine kinasesinhibitor withIC₅₀s of 0.3, 1.7 and 6.6 nM againstLyn,AblandCsk, respectively. PD173952 is also a potentMyt1kinase inhibitor with aK_iof 8.1 nM. PD173952 inducesapoptosis^[1]^[2].

IC₅₀& Target^[1]^[2]

Lyn

0.3 nM (IC₅₀)

Abl

1.7 nM (IC₅₀)

Csk

6.6 nM (IC₅₀)

Myt1

8.1 nM (Ki)

体外研究
(In Vitro)

PD173952 (0-1000 nM; 12 h) 以浓度依赖方式抑制 K562 细胞中 p210^Bcr-Abl和 CrkL 的酪氨酸磷酸化^[1]。
PD173952 (0.5 μM; 1-4 days) 抑制 K562 细胞活力^[1]。
PD173952 (0.5 μM; 24 and 48 h) 诱导 K562 和 MEG-01 细胞凋亡^[1]。

Western Blot Analysis^[1]

Cell Line:	K562 cells
Concentration:	0, 25, 50, 100, 200, 500 and 1000 nM
Incubation Time:	12 h
Result:	Inhibited tyrosine phosphorylation of p210^Bcr-Abland CrkL.

Cell Viability Assay^[1]

Cell Line:	K562 cells
Concentration:	0.5 μM
Incubation Time:	1-4 days
Result:	Caused cell death in a time-dependent manner.

Western Blot Analysis^[1]

Cell Line:	K562 and MEG-01 cells
Concentration:	0.5 μM
Incubation Time:	24 and 48 h
Result:	85-kDa PARP fragment was detected.

分子量

482.36

Formula

C₂₄H₂₁Cl₂N₅O₂

CAS 号

305820-75-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.