M5N36

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M5N36

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2832887-40-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

M5N36 是一种有效的选择性Cdc25C抑制剂，对 Cdc25A、Cdc25B、Cdc25C 的IC₅₀值分别为 0.15、0.19、0.06 μM。M5N36 显示出抗增殖活性并增加 p-CDK1 和 p-CDK2 的表达。

生物活性

M5N36 is a potent and selectiveCdc25Cinhibitor withIC₅₀values of 0.15, 0.19, 0.06 μM for Cdc25A, Cdc25B, Cdc25C, respectively. M5N36 shows anti-proliferative activity and increases the expression of p-CDK1 and p-CDK2^[1].

IC₅₀& Target

IC₅₀: 0.15 μM (Cdc25A); 0.19 μM (Cdc25B); 0.06 μM (Cdc25C)^[1]

体外研究
(In Vitro)

M5N36 (5, 10 μM; 24 h) 增加 MDA-MB-231 细胞中 p-CDK1 和 p-CDK2 的表达^[1]。

Cell Proliferation Assay^[1]

Cell Line:	Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells
Concentration:
Incubation Time:
Result:	Showed anti-proliferative activity with IC₅₀s of 2.88, 3.57, 10.00, 2.00, 1.20, 6.03, 3.39, 2.40 μM for Eca-109, HepG2, MCF-TAM, MDA-MB-231, Raji, SGC-7901, SW-620, HUVEC cells, respectively.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231 cells
Concentration:	5, 10 μM
Incubation Time:	24 h
Result:	Increased the expression of Cdc25A, Cdc25B, increased the expression of p-CDK1 and p-CDK2.

分子量

409.83

Formula

C₂₀H₁₆ClN₅O₃

CAS 号

2832887-40-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.