Abciximab

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Abciximab

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

143653-53-6

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品名称

C7E3

产品介绍

Abciximab (C7E3) 是一种小鼠/人嵌合单克隆抗体，是一种糖蛋白 IIb/IIIa (glycoprotein IIb/IIIa) 抑制剂。 Abciximab 通过与糖蛋白 IIb/IIIa、vitronectin 和 Mac-1 受体结合抑制血小板聚集和白细胞粘附。

生物活性

Abciximab (C7E3), a chimeric mouse/human monoclonal antibody, is aglycoprotein(GP) IIb/IIIainhibitor. Abciximab inhibits platelet aggregation and leucocyte adhesion by binding to theglycoprotein IIb/IIIa, vitronectin and Mac-1 receptors^[1].

体外研究
(In Vitro)

Abciximab (C7E3) inhibits platelet aggregation induced by physiologic and pathologic agonists by binding to the platelet α_IIbβ₃integrin^[2].
Abciximab appears to have similar affinity for the α_IIbβ₃and α_vβ₃integrins and redistributes between them^[2].

体内研究
(In Vivo)

Abciximab (C7E3) (0.25 mg/kg/day; i.v.; 28 days) effectively prevents neointimal hyperplasia^[2].

Animal Model:	Male Wistar rats weighing 200-250 g, balloon angioplasty model^[2]
Dosage:	0.25 mg/kg/day
Administration:	Intravenous injection, 28 days
Result:	Time-dependently inhibited both neointimal hyperplasia and lumen occlusion after angioplasty in carotid arteries of rats. Significantly reduced PDGF-BB expression in vessel lumens and neointimal smooth muscle cells after angioplasty. Suppressed the elevation of plasma TxB₂concentration.

Clinical Trial

CAS 号

143653-53-6

中文名称

阿昔单抗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.