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Cyclo(Arg-Gly-Asp-D-Phe-Val)TFA
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Cyclo(Arg-Gly-Asp-D-Phe-Val)TFA图片
CAS NO:199807-33-5
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议

产品介绍
Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 是一种整合素αvβ3抑制剂。Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 具有抗肿瘤活性。Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) 可用于急性髓系白血病的研究。
生物活性

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) is anintegrinαvβ3inhibitor. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) has antitumor activity. Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) can be used for the research of acute myeloid leukemia[1].

IC50& Target

αvβ3[1]

体外研究
(In Vitro)

Cyclo(Arg-Gly-Asp-D-Phe-Val) (TFA) (c(RGDfV)) (35 nM, 4-24 h) disruptes the adhesion and migration between the tumor cells and the matrix, induces the leukemia cells to leave the protective microenvironment and increases their sensitivity to cell cycle-dependent agents[1].

Cell Cycle Analysis[1]

Cell Line:MV4-11 cells
Concentration:35 nM
Incubation Time:24 h
Result:Affected the leukemia cell cycle, decreased the G0/G1 phase of leukemia cells in the 3D and 2D culture systems and increased the S phase of leukemia cells in the 3D and 2D culture systems.

Apoptosis Analysis[1]

Cell Line:MV4-11 cells
Concentration:35 nM
Incubation Time:24 h
Result:Increased the apoptosis rates.
分子量

688.65

性状

Solid

Formula

C28H39F3N8O9

CAS 号

199807-33-5

Sequence Shortening

Cyclo(RGD-{d-Phe}-V)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder-80°C2 years
-20°C1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)