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CBP/p300-IN-20
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CBP/p300-IN-20图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
CBP/p300-IN-20 是一种有效和选择性的p300/CBP抑制剂,对 p300 的pIC50为 10.1。CBP/p300-IN-20 可用于癌症相关研究。
生物活性

CBP/p300-IN-20 is a potent and selectivep300/CBPinhibitor, with apIC50of 10.1 for p300. CBP/p300-IN-20 can be used for the research ofcancer[1].

IC50& Target[1]

CBP/p300

10.1 (pIC50)

体外研究
(In Vitro)

CBP/p300-IN-20 (compound 28) decreases Myc protein in cell-based cMyc HTRF assay, with a pEC50of 8.5[1].
CBP/p300-IN-20 (1 μM) shows 97% inhibition for p300 and 80% inhibition for CPB[1].
CBP/p300-IN-20 (0.3-1000 nM; 2 h) decreases H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3 in COLO 320HSR cells[1].

Western Blot Analysis[1]

Cell Line:COLO 320HSR cells
Concentration:0.3, 1, 3, 10, 30, 100, 300, 1000 nM
Incubation Time:2 hours
Result:Caused a rapid concentration-dependent decrease in H3K18 and H3K27 acetylation without affecting H3K9 acetylation and total H3.
体内研究
(In Vivo)

CBP/p300-IN-20 (compound 28) (0.54 mg/kg; i.v.) exhibits Cmax(210 ng/mL), AUC0→∞(102 hong/mL), CL (95 mL/min/kg), and T1/2(0.3 h) in rats[1].

分子量

477.87

Formula

C22H19ClF3N5O2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.