Dobutamine 是合成的儿茶酚胺，作用于肾上腺素能受体α1-AR,β1-AR和β2-AR。Dobutamine 是一种选择性的 β1-AR 受体激动剂,对 α1-AR 和 β2-AR 作用相对较弱。Dobutamine 可增加心输出量，矫正低灌注。
| 生物活性 | Dobutamine is a synthetic catecholamine that acts onα1-AR, β1-AR, β2-AR (α-1, β-1 andβ-2 adrenoceptors). Dobutamine is a selective β1-AR agonist, relatively weak activity at α1-AR and β2-AR. Dobutamine can increase cardiac output and correct hypoperfusion[1][2][3][4]. |
体内研究
(In Vivo) | Dobutamine has a rapid onset of action and a short half-life[2].
Dobutamine (0.15-20 mg/kg; i.p.) results in subsequent increase in the left ventricular function and heart rate acceleration with an increasing dose in wildtype mice[3].
Dobutamine results in significant inotropic, lusitropic, and chronotropic cardiac response with a high dose in wildtype mice[3].
Low doses of Dobutamine significantly increases inotropic and lusitropic cardiac performance without chronotropic changes in the Tgαq*44 mice[3].
Dobutamine increases heart rate only after high doses, but then inotropic and lusitropic cardiac functional reserve is lost[3].
Dobutamine increases alveolar liquid clearance in ventilated rats by beta-2 receptor stimulation[4].
| Animal Model: | Tgαq*44 mice (heart failure models)[3] | | Dosage: | 0.15 mg/kg, 0.5 mg/kg as a low dose, 1.5 mg/kg, 5 mg/kg, 20 mg/kg as a high dose | | Administration: | Intraperitoneal injection | | Result: | Induced different response in cardiac function on a low and high dose in mice with with heart failure. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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