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Timolol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Timolol图片
CAS NO:26839-75-8
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Timolol 是一种β受体阻滞剂,可用于局部和全身给药。局部 Timolol 要用于降低开角型青光眼和高眼压。Timolol 还可用于婴儿血管瘤、高血压、心肌梗塞、偏头痛预防和心房颤动的研究。Timolol 还具有保护心脏的作用。
生物活性

Timolol is aβ-blockeravailable for both topical and systemic administration. Topical Timolol is primarily used to reduce intraocular pressure with open-angle glaucoma and ocular hypertension. Timolol can also be used for the research of infantile hemangiomas, hypertension, myocardial infarction, migraine prophylaxis, and atrial fibrillation.Timolol also has cardioprotective effect[1][2].

IC50& Target

β adrenergic receptor

 

体外研究
(In Vitro)

Timolol can significantly prevent the increased lipid peroxidation level of the heart from diabetic rats. Timolol can induce a well-balanced ratio between oxidative stress and antioxidant defense system in the diabetic animals, can have an important cardioprotection against diabetes-induced ERS and associated apoptotic effects[3].

体内研究
(In Vivo)

Timolol has a cardioprotective effect via inhibition of ERS response in diabetic rats[3].

Animal Model:Experimental diabetes model: 3-month old male Wistar rats[3].
Dosage:5 mg/kg
Administration:Timolol (5 mg/kg daily for 12-week)
Result:Showed cardioprotective effect.
Clinical Trial
分子量

316.42

Formula

C13H24N4O3S

CAS 号

26839-75-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.