Metamizole sodium

立即咨询

Metamizole sodium

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

68-89-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

安乃近

产品介绍

Metamizole sodium 是一种非阿片化合物，具有良好的解热的效果，可用于缓解疼痛的研究。Metamizole sodium 是一种环氧合酶-3 (COX-3) 抑制剂。

生物活性

Metamizole sodium is a non-opioid compound with excellent analgesic and antipyretic effects. Metamizole (sodium) is acyclooxygenase-3 (COX-3)inhibitor^[1]^[2].

IC₅₀& Target

COX-3^[2]

体外研究
(In Vitro)

Metamizole sodium inhibits COX-3 with an IC₅₀value of 52 μM and COX-1 at a 6.6-fold higher concentration in insect cells^[2].
Metamizole (1-500 μM; 48 hours) significantly inhibits cell proliferation in pancreatic cancer cells^[3].

Cell Proliferation Assay^[3]

Cell Line:	Pancreatic cancer cell lines PaTu 8988t and Panc-1
Concentration:	1 μM, 10 μM, 100 μM, 250 μM, 500 μM
Incubation Time:	48 hours
Result:	Significantly inhibited cell proliferation in the PaTu 8988t cell line; significantly inhibited cell proliferation in the pancreatic cancer cell line Panc-1 at 1-250 μM.

体内研究
(In Vivo)

Metamizole sodium (500 mg/kg; i.p.; twice a day; for 7 days) diminishes the development of neuropathic pain symptoms in rats^[4].

Animal Model:	Male Wistar rats (270-300 g), with peripheral neuropathic pain^[4]
Dosage:	500 mg/kg
Administration:	Intraperitoneal injection, twice a day, for 7 days
Result:	Diminished the expression of pronociceptive interleukins (IL-1beta, IL-6, and IL-18) and chemokines (CCL2, CCL4, and CCL7) in DRG measured 7 days after sciatic nerve injury.

Clinical Trial

分子量

333.34

Formula

C₁₃H₁₆N₃NaO₄S

CAS 号

68-89-3

中文名称

安乃近

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.