l-Naproxen ((R)-Naproxen) 是 (S)-Naproxen 的对映体异构体，l-Naproxen 可抑制Cdc42和Rac1(EC50分别为 96 μM 和 212 μM)，并表现出抗肿瘤活性，l-Naproxen 是一类非甾体抗炎剂。
| 生物活性 | l-Naproxen ((R)-Naproxen) is an enantiomer of (S)-Naproxen. l-Naproxen can inhibitCdc42andRac1(EC50=96 μM and 212 μM, respectively), and show anti-tumor activity. l-Naproxen is a nonsteroidal antiinflammatory drug (NSAID)[1][2][3]. |
体外研究
(In Vitro) | l-Naproxen (30-1000 μM; 2 h) inhibits Rac1 and Cdc42 activity selectively in HeLa cells[3].
l-Naproxen (0-300 μM; 48 h) inhibits migration of immortalized human ovarian cancer cells[3].
l-Naproxen (300 μM; 48 h) shows activity via a COX-independent mechanism[3].
Cell Viability Assay[3] | Cell Line: | HeLa cells | | Concentration: | 30-1000 μM | | Incubation Time: | 2 hour | | Result: | Inhibited Rac1 and Cdc42 activity in a dose dependent manner with the EC50values of 212 μM and 96 μM, respectively. |
Cell Migration Assay[3] | Cell Line: | OvCa429 and OvCa433 cells | | Concentration: | 0-300 μM | | Incubation Time: | 48 hour | | Result: | Inhibited migration of immortalized human ovarian cancer cells at 300 μM. |
Western Blot Analysis[3] | Cell Line: | OvCa433 cells | | Concentration: | 300 μM | | Incubation Time: | 48 hour | | Result: | Exhibited higher levels of phosphorylated EGFR (pEGFR) and (pERK) compared to unstimulated controls. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | 4°C | 2 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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