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Rofecoxib-d5
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rofecoxib-d5图片
CAS NO:544684-93-7
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
罗非考昔 d5
产品介绍
Rofecoxib (D5) (MK 966 (D5)) 是 Rofecoxib 的氘代物。Rofecoxib 是一种有效的,可口服的COX-2特异性抑制剂,在人骨肉瘤细胞和中国仓鼠卵巢细胞中,对人 COX-2 的IC50值分别为 26 和 18 nM;Rofecoxib 对 COX-2 的选择性是对人 COX-1 的 1000 倍,在 U937 细胞和中国仓鼠卵巢细胞中,IC50值分别为 >50 μM 和 >15 μM。
生物活性

Rofecoxib D5 (MK 966 D5) is the deuterium labeled Rofecoxib. Rofecoxib is a potent, specific and orally activeCOX-2inhibitor, withIC50s of 26 and 18 nM for humanCOX-2in human osteosarcoma cells and Chinese hamster ovary cells, with a 1000-fold selectivity forCOX-2over humanCOX-1(IC50>50 μM in U937 cells and >15 μM in Chinese hamster ovary cells)[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

319.39

Formula

C17H9D5O4S

CAS 号

544684-93-7

中文名称

罗非考昔 d5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.