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Tolfenamic Acid-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tolfenamic Acid-d4图片
CAS NO:1246820-82-5
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品名称
托芬那酸 D4
产品介绍
Tolfenamic Acid-D4 (GEA 6414-D4) 是 Tolfenamic Acid 的氘代物。Tolfenamic Acid (GEA 6414) 是一种非甾体抗炎剂和抗癌剂,能够选择性地抑制COX-2的活性,在 LPS 诱导的犬 DH82 单核细胞/巨噬细胞中,对COX-2IC50值为 13.49 μM (3.53 μg/mL),对 COX-1 无作用。
生物活性

Tolfenamic Acid-D4 (GEA 6414-D4) is the deuterium labeled Tolfenamic Acid. Tolfenamic Acid (GEA 6414) is a non-steroidal anti-inflammatory and anti-cancer agent, selectively inhibitsCOX-2, with anIC50of 13.49 μM (3.53 μg/mL) in LPS-treated (COX-2) canine DH82 monocyte/macrophage cells, but shows no effect onCOX-1[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

分子量

265.73

Formula

C14H8D4ClNO2

CAS 号

1246820-82-5

中文名称

托芬那酸 D4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.