Mapracorat

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Mapracorat

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

887375-26-0

包装与价格：

包装	价格(元)
10 mM * 1 mL in DMSO	电议
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

ZK-245186
BOL-303242X

产品介绍

Mapracorat 是新型的非甾类有选择性的glucocorticoid receptor激动剂。

生物活性

Mapracorat is a novel non-steroidal selectiveglucocorticoid receptoragonist.

体外研究
(In Vitro)

Mapracorat concentration dependently inhibited TNFα secretion from activated canine PBMC with IC₅₀value of approximately 0.2 nM.

体内研究
(In Vivo)

Intradermal injection of compound 48/80 (50 μg in 50 μL saline) resulted in a clear wheal and flare reaction over the 60 min observation period. Topical pre-treatment with mapracorat (0.1%) leads to significant reduction in the wheal and flare responses compared to vehicle (acetone) treated areas.

Clinical Trial

分子量

462.48

性状

Solid

Formula

C₂₅H₂₆F₄N₂O₂

CAS 号

887375-26-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 33.6 mg/mL(72.65 mM)

*"≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.1623 mL	10.8113 mL	21.6226 mL
5 mM	0.4325 mL	2.1623 mL	4.3245 mL
10 mM	0.2162 mL	1.0811 mL	2.1623 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。