CAS NO: | 158876-82-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Rupatadine (UR-12592) is a potent, orally active and long-lasting dualPAF/H1antagonist, withKis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria[1][2][3]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Rupatadine competitively inhibits histamine-induced guinea pig ileum contraction (pA2=9.29) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4)[1]. | ||||||||
体内研究 (In Vivo) | Rupatadine blocks histamine- and PAF-induced effects in vivo, such as hypotension in rats (ID50=1.4 and 0.44 mg/kg i.v., respectively) and bronchoconstriction in guinea pigs (ID50=113 and 9.6 μg/kg i.v.)[1].
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Clinical Trial | |||||||||
分子量 | 415.96 | ||||||||
Formula | C26H26ClN3 | ||||||||
CAS 号 | 158876-82-5 | ||||||||
中文名称 | 卢帕他定 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |