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Hydroxyzine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hydroxyzine图片
CAS NO:68-88-2
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
羟嗪
产品介绍
Hydroxyzine,一种苯二氮卓抗组胺剂 (antihistamine),作为口服活性组胺 H1 受体 (histamine H1-receptor) 和血清素拮抗剂。Hydroxyzine 具有抗焦虑作用,可用于广泛性焦虑障碍的研究。
生物活性

Hydroxyzine, a benzodiazepineantihistamineagent, acts as an orally activehistamine H1-receptorand serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder[1].

IC50& Target[1]

H1Receptor

 

体外研究
(In Vitro)

Hydroxyzine dihydrochloride inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min[1].

体内研究
(In Vivo)

Hydroxyzine dihydrochloride (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine dihydrochloride (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats[3].

Clinical Trial
分子量

374.90

Formula

C21H27ClN2O2

CAS 号

68-88-2

中文名称

羟嗪

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.