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Ranitidine bismuth citrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ranitidine bismuth citrate图片
CAS NO:128345-62-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
雷尼替丁枸橼酸盐
产品介绍
Ranitidine bismuth citrate 是一种具有口服活性的组胺 H2 受体 (Histamine H2-receptor) 拮抗剂,IC50为 3.3 μM。Ranitidine bismuth citrate 对 SARS-CoV-2 感染的细胞具有高选择性。Ranitidine bismuth citrate 是抗幽门螺杆菌 (Helicobacter Pylori) 感染的常用试剂,MIC90为 16 ng/L。
生物活性

Ranitidine bismuth citrate is an orally activeHistamine H2-receptorantagonist with anIC50of 3.3 μM. Ranitidine bismuth citrate has high selectivity for SARS-CoV-2-infected cells. Ranitidine bismuth citrate is a commonly used agent anti-Helicobacter pyloriinfectionwith an MIC90value of 16 ng/L[1][2][3].

IC50& Target

IC50: 3.3 μM[1]

体外研究
(In Vitro)

Ranitidine bismuth citrate (0.1-1 μM, 5 min) is a potent irreversible inhibitor of both the ATPase (IC50=0.69 μM, Ki=0.97 μM ) and DNA-unwinding (IC50 =0.74 μM, Ki=0.39 μM) of the SARS-CoV-2 helicase[2].
Ranitidine bismuth citrate (24 hours) shows potent activity against SARS-CoV-2 with an EC50value of 2.3 μM in Vero E6 cells[2].

Cell Cytotoxicity Assay[2]

Cell Line:Monkey kidney Vero E6 cells, human colorectal Caco-2 cells
Concentration:400-3,740 μM
Incubation Time:48 hours
Result:Showed low cytotoxicity with the 50% cytotoxicity concentrations (CC50) ranging from 2.2 mM and 2.5 mM.
体内研究
(In Vivo)

Ranitidine bismuth citrate (150 mg/kg; intranasally inoculation; once daily; 4 days) suppresses SARS-CoV-2 replication, and relieves virus-associated pneumonia in a golden Syrian hamster model[2].
Ranitidine bismuth citrate (48 mg/kg, i.p.) is effective in eradicatingH. pyloriandH. mustelaein female ferrests with MIC values of 8 ng/L and 1-2 ng/L, respectively[3].
Ranitidine bismuth citrate (0.1 mg/kg, 0.3 mg/kg; p.o.) is effective in inhibiting gastric acid secretion and (1.0 mM) inhibits human pepsin isoenzymes activity[4].

Animal Model:Male and female Syrian hamsters (6–10 weeks)[1]
Dosage:150 mg/kg
Administration:Intranasally inoculation; intraperitoneally given; once daily; 4 days
Result:Suppressed SARS-CoV-2 replication, and relieved virus-associated pneumonia in a golden Syrian hamster model.
Animal Model:Female Beagle dogs (14-20 kg)[3]
Dosage:0.1 mg/kg
Administration:Oral dosed every hour, for 5 hours
Result:Inhibited gastric acid secretion.
Animal Model:Female, random-bred hooded rats (weight range 90-120 g)[4]
Dosage:0.5 mL/100 g
Administration:Pre-treated with indomethacin (5 mg/kg s.c.); oral gavage
Result:Inhibited gastric mucosal damage in the rat.
分子量

712.48

Formula

C19H27BiN4O10S

CAS 号

128345-62-0

中文名称

雷尼替丁枸橼酸盐

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.