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Arformoterol
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Arformoterol图片
CAS NO:67346-49-0
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
福莫特罗
(R,R)-Formoterol
产品介绍
Arformoterol ((R,R)-Formoterol) 是 Formoterol 的 (R,R)-对映异构体，是一种长效 β2-肾上腺素能受体 (β2-AR) 激动剂，Kd为 2.9 nM。Arformoterol 可用于慢性阻塞性肺疾病 (COPD) 的研究。
生物活性

Arformoterol ((R,R)-Formoterol), the (R,R)-enantiomer of Formoterol, is a long-actingβ2-adrenergic receptor (β2-AR)agonist, with aKdof 2.9 nM. Arformoterol can be used for the research of chronic obstructive pulmonary disease (COPD)[1][2].

IC50& Target[1]

Beta-2 adrenergic receptor

2.9 nM (Kd)

体外研究
(In Vitro)

Arformoterol induces cAMP accumulation in cultured human bronchial epithelial cells[1].

体内研究
(In Vivo)

Arformoterol (10 ng in 0.1 ml saline/20 g body weight; intranasal instillation) mitigates Cl2-induced increases of respiratory system resistance and elastance in mice[3].
Arformoterol reverses histamine- and ovalbumin-induced bronchoconstriction in guinea pigs (ED50s=1 and 40 nmol/kg, respectively)[1].

Animal Model:Wild-type and iNOS–/–mice were exposed to Cl2gas[3]
Dosage:10 ng in 0.1 ml saline/20 g body weight
Administration:Intranasal instillation in the external nares at 10 minutes and every 24 hours after exposure
Result:Significantly mitigated the Cl2-induced increases of respiratory system resistance and elastance.
Increased cAMP in the lungs of Cl2-exposed mice.
Not mitigated Cl2-induced lung injury and inflammation.
分子量

344.40

性状

Solid

Formula

C19H24N2O4

CAS 号

67346-49-0

中文名称

福莫特罗

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month