Angoline hydrochloride

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CAS NO:	1071676-04-4
包装:	5mg
市场价:	1800元

产品介绍

Angoline hydrochloride 是一种有效的、选择性的IL6/STAT3信号通路抑制剂，IC₅₀为 11.56 μM。Angoline hydrochloride 抑制 STAT3 磷酸化及其靶基因表达，并抑制癌细胞增殖。

生物活性

Angoline hydrochloride is a potent and selectiveIL6/STAT3 signaling pathwayinhibitor with anIC₅₀of 11.56 μM. Angoline hydrochloride inhibitsSTAT3phosphorylation and its target gene expression, and inhibitscancercell proliferation^[1].

IC₅₀& Target

IC50: 11.56 μM (IL6/STAT3 signaling pathway), 3.32 μM (MDA-MB-231), 4.72 μM (H4), 3.14 μM (HepG2)^[1]

体外研究
(In Vitro)

Angoline hydrochloride (0-100 μM; 1 h) inhibits STAT3, STAT1 and NF-κB signaling pathways with IC₅₀values of 11.56, ＞100 and ＞100 μM, respectively^[1].
Angoline hydrochloride (0-100 μM; 2 h) affects phosphorylation of STAT3^[1].
Angoline hydrochloride (0-100 μM; 72 h) inhibits MDA-MB-231, H4 and HepG2 cells proliferation^[1].

Western Blot Analysis^[1]

Cell Line:	HepG2/STAT3 cell lines
Concentration:	0, 1, 10, 30 and 100 μM
Incubation Time:	2 hours
Result:	Inhibited IL-6-induced phosphorylation of STAT3 in HepG2/STAT3 cells.

Western Blot Analysis^[1]

Cell Line:	MDA-MB-231, H4 and HepG2 cell lines
Concentration:	0-100 μM
Incubation Time:	72 hours
Result:	Inhibited proliferation of MDA-MB-231, H4 and HepG2 cells with IC₅₀values of 3.32, 4.72 and 3.14 μM, respectively.

分子量

415.87

Formula

C₂₂H₂₂ClNO₅

CAS 号

1071676-04-4

结构分类

Alkaloids
Isoquinoline Alkaloids

来源

Plants
Papaveraceae
Macleaya cordata(Willd.) R. Br.

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.