GYKI 52466 dihydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

2319722-40-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

GYKI 52466 dihydrochloride 是一种具有口服活性、高选择性和非竞争性的AMPA/Kainate受体拮抗剂，其IC₅₀值分别为 7.5 和 11 μM。GYKI 52466 dihydrochloride 具有良好的血脑屏障通透性和抗惊厥作用，可用于帕金森病的研究。

生物活性

GYKI 52466 dihydrochloride is an orally active, highly selective and noncompetitiveAMPA/kainate receptorantagonist with theIC₅₀values of 7.5 and 11μM, respectively. GYKI 52466 dihydrochloride has good blood brain barrier permeability and anticonvulsant effect. GYKI 52466 dihydrochloride can be used in Parkinson's disease research^[1]^[2].

IC₅₀& Target^[1]

AMPA Receptor

7.5 μM (IC₅₀)

Kainate Receptor

11 μM (IC₅₀)

体外研究
(In Vitro)

GYKI 52466 (0.3-100 μM) inhibits inward currents activated by AMPA and Kainate receptor in cultured rat hippocampal neurons^[1].

体内研究
(In Vivo)

GYKI 52466 (intraperitoneal injection; 1.76-13.2 mg/kg; once) treatment provides potent anticonvulsant protection against sound-induced seizures in DBA/2 mice^[2].

Animal Model:	Male and female DBA/2 mice tested for sound-induced seizure responses^[2]
Dosage:	1.76-13.2 mg/kg
Administration:	Intraperitoneal injection; 1.76-13.2 mg/kg; once
Result:	Observed Maximal anticonvulsant protection after the i.p. treatment (5-15 min ).

分子量

366.24

性状

Solid

Formula

C₁₇H₁₇Cl₂N₃O₂

CAS 号

2319722-40-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)