Pectin is a heteropolysaccharide, derived from the cell wall of higherplants. Pectin involves in the formation of nanoparticles as a delivery vehicle of drugs. Pectin is also an adsorbent, a broad-spectrum antimicrobial agent that binds to bacteria toxins and other irritants in the intestinal mucosa, relieves irritated mucosa^[1][2][3].

Pectin (5 mg/mL; 24, 48, and 72 h) shows low cytotoxicity on HepG2 cells, and can be made into nanoparticles (PPN), encapsulatingPaclitaxel(HY-B0015), decreases the Paclitaxel cytotoxicity (%) from 55.6% to 21.7% at 72 h^[1].
Pectin (3, 6 mg/mL; 48 h) inhibitsStaphylococcus aureusATCC 25923 growth, with a minimum inhibitory concentration (MIC) of 40 mg/mL^[2].
Pectin inhibits Gram-negativeHelicobacter pylori, a common human pathogen, shows highest antibacterial activity at pH 5.0, with a minimum inhibitory concentration (MIC) of 0.162 mg/mL and minimum bactericidal concentration (MBC) of 0.325 mg/mL^[2].
Pectin displays lower antibacterial activity againstE. coliwith MICs of 25 mg/mL and 50 mg/mL and MBC values ranging between 25-50 mg/mL^[2].
Pectin exhibits the antibacterial activity via its undissociated acid form^[2].

Pectin serves as the nanoparticles encapsulatingPaclitaxel(HY-B0015), (20 mg/kg; i.v.; single dose) significantly delays plasma clearance with detection of Paclitaxel possible up to 48 h in Balb/c mice^[1].

9000-69-5

• Saccharides
• Polysaccharides

• Others

• Plants
• Rosaceae
• Malus pumilaMill.

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.