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Kushenol A
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Kushenol A图片
CAS NO:99217-63-7
包装与价格:
包装价格(元)
10 mM * 1 mL in DMSO电议
5mg电议
10mg电议
50mg电议
100mg电议

产品名称
Leachianone E
产品介绍
Kushenol A (Leachianone E) 从苦参根中分离出来的。Kushenol A 是一种非竞争性酪氨酸酶 (tyrosinase) 抑制剂,可阻止 L-tyrosinase 转化为 L-DOPA,IC50Ki值分别为 1.1 μM 和 0.4 μM。Kushenol A 是一种类黄酮抗氧化剂,对 α-葡萄糖苷酶 (alpha-glucosidase) (IC50: 45 μM;Ki: 6.8 μM) 和 β-淀粉酶 (beta-amylase) 具有抑制作用。Kushenol A 被认为是化妆品针对皮肤美白和衰老的潜在酶抑制剂。
生物活性

Kushenol A (Leachianone E) is isolated from the root ofSophora flavescent. Kushenol A is a non-competitivetyrosinaseinhibitor to block the conversion of L-tyrosine to L-DOPA, showsIC50andKivalues of 1.1 μM and 0.4 μM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM;Ki: 6.8 μM) and β-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1].

IC50& Target

IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)[1][2]

体外研究
(In Vitro)

Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC50value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM[1].
Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50value of 57.2 μg/ml for BEAS-2B cells[3].

Cell Viability Assay[3]

Cell Line:NSCLC cell lines, A549 and NCI-H226
Normal human lung epithelial: BEAS-2B
Concentration:0-60 μg/ml
Incubation Time:24 hours
Result:Exhibited considerable cytotoxic effects against NSCLC cells.
分子量

408.49

性状

Solid

Formula

C25H28O5

CAS 号

99217-63-7

中文名称

苦参新醇A

结构分类
  • Flavonoids
  • Flavonones
  • Phenols
  • Polyphenols
来源
  • Plants
  • Leguminosae
  • Sophora flavescens
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 100 mg/mL(244.80 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.4480 mL12.2402 mL24.4804 mL
5 mM0.4896 mL2.4480 mL4.8961 mL
10 mM0.2448 mL1.2240 mL2.4480 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。