CAS NO: | 99217-63-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
生物活性 | Kushenol A (Leachianone E) is isolated from the root ofSophora flavescent. Kushenol A is a non-competitivetyrosinaseinhibitor to block the conversion of L-tyrosine to L-DOPA, showsIC50andKivalues of 1.1 μM and 0.4 μM, respectively[1]. Kushenol A is a flavonoid antioxidant, has inhibitory effects on alpha-glucosidase (IC50: 45 μM;Ki: 6.8 μM) and β-amylase[2]. Kushenol A is confirmed as potential inhibitors of enzymes targeted by cosmetics for skin whitening and aging[1]. | ||||||||||||||||
IC50& Target | IC50: 1.1 μM (tyrosinase); 45 μM (alpha-glucosidase)[1][2] | ||||||||||||||||
体外研究 (In Vitro) | Kushenol A (25 μM) exhibits a highly potent inhibitory activity on ABTS+ radical scavenging with an IC50value of 9.7 ± 0.1 μM, and exhibits inhibits scavenging activity as a percentage 93.7% at 25 μM[1].Kushenol A (0-60 μg/ml; 24 hours) shows considerable cytotoxic effects against NSCLC cells, exhibits IC50values of 5.3 μg/ml and 20.5 μg/ml for A549 and NCI‐H226 cells, respectively. It shows an IC50value of 57.2 μg/ml for BEAS-2B cells[3]. Cell Viability Assay[3]
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分子量 | 408.49 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C25H28O5 | ||||||||||||||||
CAS 号 | 99217-63-7 | ||||||||||||||||
中文名称 | 苦参新醇A | ||||||||||||||||
结构分类 |
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来源 |
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运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(244.80 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 |