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Succinyl phosphonate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Succinyl phosphonate图片
CAS NO:26647-82-5
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Succinyl phosphonate 是 α-酮戊二酸脱氢酶 (KGDHC) 抑制剂,可有效抑制肌肉,细菌,脑和人成纤维细胞中的 KGDHC。Succinyl phosphonate trisodium salt 抑制 2-氧代戊二酸脱氢酶 (OGDH),以细胞特异性代谢依赖性方式损害癌细胞的活力。Succinyl phosphonate trisodium salt 抑制谷氨酸诱导的谷氨酸刺激的海马神经元中的ROS产生。
生物活性

Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle,bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability ofcancercells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-inducedROSproduction in glutamate-stimulated hippocampal neurons in situ[3].

IC50& Target

α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase[1][4]; ROSproduction[3]

分子量

182.07

性状

Oil

Formula

C4H7O6P

CAS 号

26647-82-5

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Pure form-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month