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Quinagolide hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Quinagolide hydrochloride图片
CAS NO:94424-50-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
盐酸喹高利特
CV205-502 hydrochloride
产品介绍
Quinagolide hydrochloride (CV205-502 hydrochloride) 是选择性的、具有口服活性的多巴胺D2 受体激动剂。Quinagolide hydrochloride 是催乳素抑制剂。Quinagolide hydrochloride 下调AKT的水平及其磷酸化。Quinagolide hydrochloride 具有抗肿瘤活性,可用于癌症的研究。
生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamineD2 receptoragonist. Quinagolide hydrochloride is an inhibitor ofprolactin. Quinagolide hydrochloride down-regulatesAKTlevels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research ofcancer[1][2].

体外研究
(In Vitro)

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines[2].
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)[2].
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs[2].

Western Blot Analysis[2]

Cell Line:Eutopic and ectopic E-MSCs
Concentration:100 nM
Incubation Time:24 h
Result:Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.
体内研究
(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo[1].

Animal Model:Female Wistar-Furth rats bearing SMtTW tumors[1]
Dosage:0.03-0.6 mg/kg
Administration:Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result:Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.
Clinical Trial
分子量

432.02

性状

Solid

Formula

C20H34ClN3O3S

CAS 号

94424-50-7

中文名称

盐酸喹高利特

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 3.85 mg/mL(8.91 mM;Need ultrasonic)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.3147 mL11.5735 mL23.1471 mL
5 mM0.4629 mL2.3147 mL4.6294 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。