Monomethyl lithospermate

立即咨询

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

933054-33-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Lithospermic acid monomethyl ester

产品介绍

Monomethyl lithospermate 激活PI3K/AKT通路，对神经损伤发挥保护作用。Monomethyl lithospermate 能提高 SHSY-5Y 细胞的生存能力，抑制线粒体膜电位 (MMOP) 崩溃，抑制细胞凋亡。Monomethyl lithospermate 还降低中动脉闭塞 (MCAO) 大鼠脑组织中的氧化应激水平，改善缺血性中风 (IS) 大鼠神经损伤。

生物活性

Monomethyl lithospermate activates thePI3K/AKTpathway, which plays a protective role in nerve injury. Monomethyl lithospermate can improve the survival ability of SHSY-5Y cells, inhibit the breakdown of mitochondrial membrane potential (MMOP) and inhibit cellapoptosis. Monomethyl lithospermate also reduced the level of oxidative stress in the brain tissue of rats with middle artery occlusion (MCAO) and improved nerve damage in rats with ischemic stroke (IS)^[1].

体外研究
(In Vitro)

Monomethyl lithospermate (5、10 和 20 μM; 12 h) 提高氧-葡萄糖剥夺和再灌注 (OGD/R) 处理的 SHSY-5Y 细胞的细胞活力^[1]。
Monomethyl lithospermate (20 μM; 12 h) 可减轻 SHSY-5Y 细胞在缺氧、葡萄糖剥夺/复氧后的细胞损伤、线粒体膜电位损失和细胞凋亡^[1]。
Monomethyl lithospermate (5、10 和 20 μM; 12 h) 减少 SHSY-5Y 细胞的 ROS 和细胞内氧化应激^[1]。
Monomethyl lithospermate (20 μM; 12 h) 可激活 SHSY-5Y 细胞的 PI3K/AKT^[1]。

Immunofluorescence^[1]

Cell Line:	SHSY-5Y cells
Concentration:	5, 10, and 20 μM
Incubation Time:	12 hours
Result:	Inhibited the mitochondrial membrane potential (MMOP) collapse and apoptosis of SHSY-5Y cells induced by oxygen and glucose deprivation/Reoxygenation (OGD/R) treatment.

体内研究
(In Vivo)

Monomethyl lithospermate (72.4 μM/kg; 口服; 每日 1 次, 连续 14 天) 改善改善缺血再灌注 (IR) 24 h 后中动脉闭塞 (MCAO) 大鼠的神经功能，减少脑梗死面积；可降低 MCAO 大鼠氧化应激水平，抑制神经元凋亡^[1]。
Monomethyl lithospermate 通过激活 PI3K/AKT 改善缺血-再灌注诱导的神经损伤^[1]。

分子量

552.48

Formula

C₂₈H₂₄O₁₂

CAS 号

933054-33-2

结构分类

Phenols
Polyphenols

来源

Plants
Compositae
Hemistepta lyrata

Plants
Labiatae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.