PZ703b TFA

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PZ703b TFA

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议

产品介绍

PZ703b TFA 是一种 Bcl-xlPROTAC降解剂，可以诱导细胞凋亡 (apoptosis)，抑制癌细胞增殖，用于膀胱癌研究。

生物活性

PZ703b TFA is aBcl-xlPROTACdegradation agent that inducesapoptosisand inhibitscancercell proliferation for bladdercancerresearch^[1]^[2].

体外研究
(In Vitro)

PZ703b (0-1 μM, 24 h) TFA can synergistically inhibit bladder cancer cell proliferation with Mivebresib in a dose-dependent manner and induce apoptosis in bladder cancer cells via the mitochondrial pathway^[1].
PZ703b (0-1 μM, 48 h) TFA inhibits MOLT-4 and RS4;11 cells with the IC₅₀values of 15.9 and 11.3 nM respectively^[2].
PZ703b (10 nM, 48 h)TFA induces rapid and durable BCL-XL degradation and apoptosis in MOLT-4 cells through the caspase-3 mediated pathway^[2].

Apoptosis Analysis^[1]

Cell Line:	Bladder cancer cell lines 5637, SW780, and HT-1977
Concentration:	1 μM
Incubation Time:	24 hours
Result:	Induction of Bcl-xl degradation increased the association between Mcl-1 and Bim (a pro-apoptotic Bcl-2 protein). It was further shown that forced expression of Bcl-xl or Mcl-1 significantly reduced PZ703b-induced apoptosis. Resulted in a slight activation of Bax and Bak.

分子量

1714.46

性状

Solid

Formula

C₈₂H₁₀₃ClF₆N₁₀O₁₃S₄

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)