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L-Biopterin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
L-Biopterin图片
CAS NO:22150-76-1
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议

产品介绍
L-Biopterin (L-Biopterin) 是蝶呤衍生物，是一种 NO 合酶辅因子。
Cas No.22150-76-1
别名L-生物喋呤,L-erythro-Biopterin,NSC 339699
化学名2-amino-6-[(1R,2S)-1,2-dihydroxypropyl]-4(1H)-pteridinone
Canonical SMILESNC(N=C1C2=NC([C@@H](O)[C@@H](O)C)=CN1[H])=NC2=O
分子式C9H11N5O3
分子量237.2
溶解度≤1mg/ml in DMSO;0.3mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Biopterin is the oxidized form of tetrahydrobiopterin (BH4) [1].

Tetrahydrobiopterin (BH4) has been also known as sapropterin. BH4 is an essential cofactor of the three aromatic amino acid hydroxylase enzymes which has used in the degradation of amino acid phenylalanine and in the biosynthesis of the neurotransmitters serotonin (5-HT), melatonin, norepinephrine, dopamine, epinephrine (adrenaline). BH4 is a cofactor of nitric oxide synthases [2].

L-Biopterin was reduced to BH4 via thioredoxin reductase followed by dihydropteridine reductase or reduced glutathione. L-Biopterin was extremely toxic to human melanocytes in culture with the IC50 of 0.2 μM after 48 hrs. L-Biopterin was rarely existed under physiological conditions except in the epidermis of patients with the depigmentation disorder Vitiligo [3].

References:
[1] Schallreuter K U, Buttner G, Pittelkow M R, et al.  Cytotoxicity of 6-biopterin to human melanocytes[J]. Biochemical and biophysical research communications, 1994, 204(1): 43-48.
[2] Calka J.  The role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons[J]. Folia Histochemica et Cytobiologica, 2006, 44(1): 3.
[3] Moore J, Wood J M, Schallreuter K U.  Evidence for Specific Complex Formation between α-Melanocyte Stimulating Hormone and 6 (R)-l-Erythro-5, 6, 7, 8-tetrahydrobiopterin using Near Infrared Fourier Transform Raman Spectroscopy[J]. Biochemistry, 1999, 38(46): 15317-15324.