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Allo-aca TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Allo-aca TFA图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Allo-aca TFA 是一种瘦素肽模拟物,是一种有效的、特异性的瘦素受体 (leptin receptor) 拮抗剂肽。Allo-aca TFA在多种体外和体内模型中阻断瘦素信号传导和作用。
生物活性

Allo-aca TFA, aleptinpeptidomimetic, is a potent, specificleptinreceptorantagonist peptide. Allo-aca TFA blocksleptinsignaling and action in numerous in vitro and in vivo models[1][2].

体外研究
(In Vitro)

Allo-aca TFA inhibits leptin-induced proliferation of MDA-MB-231 cells at 50 pM concentration. Allo-aca TFA inhibits leptin-induced proliferation of MCF-7 cells with an IC50of 200 pM[1].
Allo-aca TFA at 250 nmol/L reduces VEGF-dependent leptin mRNA expression in both cell lines below base levels. Allo-aca TFA inhibits VEGF mitogenic effects. Allo-aca TFA inhibits VEGF-induced chemotaxis and chemokinesis in RF/6A retinal endothelial cells[2].

体内研究
(In Vivo)

In an MDA-MB-231 orthotopic mouse xenograft model, Allo-aca TFA administered subcutaneously significantly extends the average survival time from 15.4 days (untreated controls) to 24 and 28.1 days at 0.1 and 1mg/kg/day doses, respectively[1].

分子量

1188.21

Formula

C50H76F3N13O17

Sequence Shortening

{H-allo}-TE-{Nva}-VALSR-{Aca}-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.