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Benfluorex
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Benfluorex图片
CAS NO:23602-78-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
JP-992
产品介绍
Benfluorex (JP-992) 是一个肝核因子 4α (HNF4α) 激活剂。
生物活性

Benfluorex (JP-992) is ahepatic nuclear factor 4 alpha(HNF4α) activator.

IC50& Target

HNF4α[1]

体外研究
(In Vitro)

Benfluorex consistently activates insulin promoter activity as measured by an increased number of GFP-positive cells. Benfluorex increases the number of GFP-positive cells in a dose-responsive manner and increases the level of endogenous insulin mRNA. Consistent with being HNF4α activator, Benfluorex stimulates HNF4α expression. Benfluorex alters HNF4α protease sensitivity, while the inactive control compound does not[1]. Benfluorex decreases, in a concentration-dependent manner, the synthesis of acid-soluble products and ketone bodies from oleate, whereas the production of14CO2into citric acid cycle is markedly increased by Benfluorex. Benfluorex inhibits in a dose-dependent manner the rates of gluconeogenesis from lactate/pyruvate (10/1 nM)[2].

Clinical Trial
分子量

351.36

Formula

C19H20F3NO2

CAS 号

23602-78-0

中文名称

苯氟雷司

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.