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Leonurine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Leonurine图片
CAS NO:24697-74-3
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品名称
益母草碱
SCM-198
产品介绍
Leonurine 是从益母草中分离到的生物碱,具有抗氧化、抗炎活性。
生物活性

Leonurine is an alkaloid isolated fromLeonurus artemisia, with anti-oxidative and anti-inflammatory.

体外研究
(In Vitro)

Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ[1]. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway[2]. Leonurine (5, 10, 20 μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner[3].

体内研究
(In Vivo)

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice[1]. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice[2]. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model[3].

分子量

311.33

性状

Solid

Formula

C14H21N3O5

CAS 号

24697-74-3

中文名称

益母草碱

结构分类
  • Alkaloids
  • Other Alkaloids
  • Phenols
  • Monophenols
来源
  • Plants
  • Labiatae
  • Leonurus artemisia(Lour.) S. Y. Hu
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO : 33.33 mg/mL(107.06 mM;ultrasonic and adjust pH to 2 with HCl)

H2O : 1 mg/mL(3.21 mM;ultrasonic and warming and heat to 80℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM3.2120 mL16.0601 mL32.1203 mL
5 mM0.6424 mL3.2120 mL6.4241 mL
10 mM0.3212 mL1.6060 mL3.2120 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。